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Abstract

EXPERIMENTAL STUDIES ON WOUND HEALING PROPERTIES OF ANDROGRAPHIS ECHIOIDES (L.) NEES IN WISTAR ALBINO RATS

Mohd Rafiq* and Dr. Sadath Ali

ABSTRACT

As we all know in the present situation medicinal plants are very much influenced by the researchers because of its minimal or no side effects. India is sitting on a gold mine of well-recorded and well practiced knowledge of traditional herbal medicine. Andrographis echioides is one of the Indian medicinal plant belongs to the family of Acanthaceae. It is widely distributed in the tropical parts of India and Srilanka. Based on the traditional value of Andrographis echioides still many activities are yet to be proven scientifically. This study was carried out to evaluate the wound healing potential of ethanolic extract of whole plant Andrographis echioides (200mg/kg/day) in Wister albino rat using excision and incision wound model in the form of ointment base. All experiments were conducted according to standard procedures. In excision model, ethanolic extract treated animals exhibit 19.50±0.34% reduction in wound area when compared to control which was 30.12±0.60% and whereas standard exhibit 18.00±0.87%. The extract treated wounds are found to epithelize faster as compared to control. In incision wound model Significant (p<0.001) increase in breaking strength 307.23±1.37 was observed where as in control group it was 119.33±6.67 and in standard it was 330.41±8.77. The Framycetin sulphate cream (FSC) 1 % w/w was used as standard.

Keywords: Andrographis echioides, Wound healing, Excision wound, Incision wound, Framycetin sulphate cream.


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