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Abstract

SYNTHESIS, CHARACTERIZATION AND INVITRO ANTIMICROBIAL ACTIVITY OF MIXED ‘TRANSITION METAL - BARIUM TARTARATE’ COMPLEXES

Milind B. Ubale*, Murlidhar A. Betallu, Vijay B. Tadke, Shridhar M. Vhankate and Girish R. Pathade

ABSTRACT

A novel series of six new mixed alkaline earth and transition metal complexes of general formulation [MM/(C4H4O6)2.xH2O] (where M= Mn, Fe, Co, Ni, Cu, Zn and M/=Ba) are synthesized by using tartarate as a bidentate ligand and are characterised by different sophisticated analytical techniques such as elemental analysis, TGA, FTIR, XRD, magnetic susceptibility study, UV-visible spectroscopy etc. From the analytical data it was observed that all complexes exhibited 1:1 (metal: ligand) ratio. IR spectral data shows that bidentate ligand coordinate with metal ion in a bidentate manner through two ‘O’ atoms. TGA of complexes shows that degradation pattern of complexes were in good agreement with recommended formulae of the complexes. XRD technique shows that all the complexes are polycrystalline in nature. The synthesized metal complexes were then tested invitro for their biological activity against Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris and E.coli to assess their antibacterial effects. The bioassays of all the complexes showed a greater inhibitory effect in the form of broad activity spectrum than the individual ligand which indicates that after the coordination, antibacterial activity is increased.

Keywords: Alkaline earth-transition metal complexes, TGA, UV-visible, Octahedral geometry, Biological activity.


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