WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

ROLE OF ANTIOXIDANTS IN SCHIZOPHRENIA

Dr. Mitchelle C. V. Menezes* and Dr. Chitra Y. Dhume

ABSTRACT

Schizophrenia is a clinical syndrome of variable, but profoundly disruptive psychopathology that involves cognition, emotion, perception and other aspects of behavior. There is increasing evidence that oxidative injury contributes to pathophysiology of Schizophrenia. Hence, identification of various oxidants and antioxidants may help to determine their possible role in the etiology and treatment of the disease. The present study assessed the oxidative stress in patients with schizophrenia by measuring serum Malonaldehyde levels and their antioxidant status by measuring blood levels of Vitamin E, Vitamin C, Reduced Glutathione and β- Carotene in a group of sixty patients. The study was conducted over a period of 18 months in the Goa Medical College and the Institute of Psychiatry and Human Behaviour. Diagnosis of Schizophrenia was made using the ICD-10 classification. A control group of sixty healthy subjects was recruited. As compared to matched controls, the acutely admitted patients suffering from Schizophrenia exhibited significantly increased lipid peroxidation products and decreased antioxidants namely Vitamin C, Vitamin E, Reduced Glutathione and β-Carotene suggesting that the oxidative damage that occurs in Schizophrenic patients exhausts the antioxidant defense of the body leading to low levels of antioxidants.

Keywords: Schizophrenia, Oxidative stress, Antioxidants.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More