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Abstract

EVALUATION OF NOOTROPIC ACTIVITY OF DIFFERENT EXTRACTS OF VIGNA MUNGO (LINN) IN RATS

Saleem Ahmed and Zeeshan Afsar*

ABSTRACT

The ethanol and aqueous seed extracts of Vigna mungo were evaluated for nootropic activity in mice. Acute oral toxicity study was performed on mice as per OECD guidelines. Scopalamine and Diazepam induced amnesia in mice were used to study the effects of extracts on learning and memory in the experimental animals using elevated plus maze. Both ethanol and aqueous extracts effectively reversed Sopalamine and Diazepam induced amnesia at a dose of 200 to 400 mg/ml by reducing transfer latency. This suggests that the extracts are capable of increasing memory and learning behavior in animals.

Keywords: Vigna mungo, Nootropic activity, Amnesia, Transfer latency, Dementia.


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