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Abstract

STUDY ON ANTICONVULSANT AND ANXIOLYTIC ACTIVITIES OF LEAVES EXTRACTS OF ACORUS CALAMUS LINN. IN MICE

Ravi Ranjan Kumar Pandey*, Dr. Shivakumar S. Inamdar, Shamabai D. Hosamani, Prateek Reddy and Anil S. Rathod

ABSTRACT

Many synthetic drugs are available for treatment of convulsions and anxiety but they have also many side effects. Therefore new anticonvulsant and anxiolytic drugs from traditional system of medicine have to be developed with less or no side effects. Among various medicinal plants Acorus calamus Linn. has been used to cure various illnesses including psychopathy. But it lacks scientific validation. Therefore the present study undertaken to evaluate the anticonvulsant and anti-anxiety activity using Picrotoxin induced convulsions model and Open-Field test respectively by using the petroleum ether, Methanolic and aqueous extracts of leaves of Acorus calamus Linn. along with acute toxicity tests. A dose of 200 mg/kg body weight of the all three extracts i.e. Petroleum ether, Methanolic and Aqueous extract of leaves of Acorus calamus Linn. showed significant anti-convulsant and anti-anxiety activity when compared to control group. But Aqueous extract having much greater anticonvulsant effect than methanolic and petroleum ether extracts, where as methanolic extract showed much anxiolytic activity than aqueous and petroleum ether extracts and acute oral toxicities test performed revealed that LD50 of the test drug was found to be greater than 2000 mg/kg body weight. The results suggest that Acorus calamus Linn. can be used as a potential anticonvulsant and anti-anxiety drug in future.

Keywords: 10.20959/wjpr20166-6392


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