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Abstract

EVALUATION OF OXIDANT AND ANTIOXIDANT STATUS AMONG CHRONIC PERIODONTITIS PATIENTS AND HEALTHY SUBJECTS

Dr. Reshama Y. Sawant* and Dr. Chitra Y. Dhume

ABSTRACT

Oxidative stress has been implicated in the pathogenesis of inflammatory condition like periodontitis. This study was carried out inorder to assess the levels of oxidants and antioxidants in the saliva sample of periodontitis patients and compare it with healthy subjects.this study comprised of 70 subjects, out of which 35 were chronic periodontitis patients and 35 were healthy subjects.saliva sample was obtained from all the subjects and analysed for levels of MDA which is a marker of oxidative stress. Also total antioxidant capacity(TAC) was determined ,alongwith individual antioxidants like vitamin C, uric acid and reduced glutathione. It was found that the levels of MDA was significantly increased in chronic periodontitis patients than healthy subjects (p<0.05). Salivary total antioxidant capacity and other antioxidants such as vitamin C and uric acid were significantly lowered in patients with chronic periodontitis as compared to healthy subjects (p<0.01). Glutathione level was also reduced in chronic periodontitis patients than healthy subjects but it was not significant. It was concluded that oxidative stress plays a significant role in the pathogenesis and progression of periodontitis. These parameters would help in evaluating the severity of the disease so that the progression of the disease can be prevented or treated with proper antioxidant therapy.

Keywords: Chronic periodontitis, MDA, Total antioxidant capacity, Uric acid.


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