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K. Lakshmi Surekha*, N. N. Srinivas Rao, C. Murali Krishna Goud, K. Ramya, U. Srikanth, G. Rajeswari, A. Sudha Rani, G. Keerthi, K. Shiva Durga Prasad, Dr. H. Ramana


Adverse drug reactions (ADR) are a significant cause of morbidity and mortality, often identified only post-mark tingly. Improvement in current ADR reporting, including utility of underused or innovative methods, is crucial to improve patient safety and public health. Hospital-based monitoring is one of the methods used to collect data about drug prescriptions and adverse events. The aims of this study were to identify the most frequent ADRs recognized by the attending physicians, study their nature, and to target these ADRs in order to take future preventive measures. A prospective study was conducted over a 3-month period in an internal medicine department using stimulated spontaneous reporting for identifying ADRs. Out of the 300 admissions, 32 ADRs in 37 patients (14.56%) were validated from the total of 36 suspected ADRs inpatients. Female predominance was noted in case of ADRs. Fifty percent of total ADRs occurred due to multiple drug therapy. Dermatological ADRs were found to be the most frequent (68.75%), followed by respiratory, central nervous system and gastrointestinal ADRs. The drugs most frequently involved were antibiotics. The most commonly reported reactions were abdomen pain and vomitings. Out of the 32 reported ADRs, 50% of the reactions were probable, 46.87% of the reactions were possible and 3.12% of the reactions were definite. The most potent management of ADRs was found to be drug withdrawal. Our study indicated that hospital based monitoring was a good method to detect links between drug exposure and adverse drug reactions. Adequate training regarding pharmacology and optimization of drug therapy might be helpful to reduce ADR morbidity and mortality.

Keywords: adverse drug reaction, hospital based monitoring, pharmacovigilance.

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