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Abstract

TO EVALUATE THE ANTI-DIABETIC ACTIVITY OF COMMERCIALLY AVAILABLE EXTRACT OF TINOSPORA CORDIFOLIA IN ANIMAL MODEL

Nishant Pathak, Arkapal Bandyopadhyay*, Rakesh Chandra Chaurasia, Kachnar Verma

ABSTRACT

Objective: To evaluate the anti-diabetic activity of commercially available extract of Tinospora cordifolia in streptozocin induced diabetic rats. Materials and Methods: The study was carried out in 30 albino rats of either sex weighing between 100-150 gm. All the rats were fed with a high fat diet for 2 weeks after which fasting blood glucose levels were taken. All the rats were intraperitonially injected with 35 mg/kg of streptozocin in citrate buffer. Blood glucose was estimated after 1 week high fat diet and rats having blood glucose >200 mg/dl were considered diabetic and included in further study. They were divided into 4 groups of 6 rats each. Group 1 had diabetic controls (distilled water).Group 2 consisted of diabetic rats receiving Tinospora cordifolia extract (200 mg/kg/day).Group 3 had diabetic rats receiving Tinospora cordifolia extract (400 mg/kg/day). Group 4 included diabetic rats receiving Glibenclamide (0.6 mg/kg/day).All the rats received allocated drugs for further 6 weeks. Blood glucose estimation was done every two months by Glucose-Oxidase method. Results: In both low as well as high dose groups, Tinospora cordifolia showed significant reduction (P <0.01) in plasma glucose levels from fourth week onwards. Conclusion: Commercially available extract of Tinospora cordifolia have significant anti-diabetic activity in streptozocin induced diabetic rats.

Keywords: Tinospora cordifolia, Diabetes mellitus, Streptozocin, Antidiabetic, Animal model, Glibenclamide.


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