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Abstract

EVALUATION OF POLY HERBAL FORMULATION AGAINST FRUCTOSE INDUCED INSULIN RESISTANCE IN RATS

M. Venkateswarlu*, D. Ranganayakulu, K. N. Jayaveera

ABSTRACT

The metabolic syndrome, a cluster of metabolic disorders often associated with visceral obesity, increases cardiovascular complications and mortality. Polyherbal therapy is said to be a current pharmacological principle having the benefit of producing maximum therapeutic efficacy with minimum side effects. The present study was carried out to evaluate hypoglycemic, lipid lowering and antioxidant activities of a poly herbal formulation (PHF) in fructose induced insulin resistance in rats. Insulin resistance was induced by administering 30% Fructose (10 ml/kg, p.o.) in rats for 4 months. Aqueous extract of PHF (400mg/kg p.o) decreased significantly (p<0.05) both blood glucose levels and insulin resistance which was indicated by decreased insulin levels and HOMA values. The PHF treated groups also significantly decreased lipid values, LDL/HDL ratio, atherogenic index values and increased HDL concentration. PHF also decreased visceral fat levels which was responsible for normalized physical parameters like body weight, waist circumference and body mass index when compared to fructose control group. Histopathological studies also supported the results. Present study revealed that PHF possesses antidiabetic and antihyperlipidemic activity and the drug had also showed improved oral glucose tolerance in diabetic rats. Thus the herbal formulation may be useful in the management of Metabolic Syndrome.

Keywords: Polyherbal formulation - Fructose - Metabolic syndrome - Insulin resistance– Experimental animals.


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