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Abstract

DEVELOPMENT AND VALIDATION OF UVSPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CYPROHEPTADINE HYDROCHLORIDE IN BULK AND TABLET FORMULATION BY CO-SOLVENCY APPROACH

Wagh Yogesh B.*, Bhushan Bhairav A. and Saudagar Ravindra B.

ABSTRACT

Simple precise accurate UV Spectroscopic method has been developed and validated for estimation of Cyproheptadine HCl in bulk and pharmaceutical dosage form. It is approved for the treatment of allergic rhinitis. It is 5-HT2 receptor antagonist. UV Spectroscopic method which is based on measurement of absorption of UV light, the spectra of Cyproheptadine HCl in Co-solvent, Methanol:Water (1:4) showed maximum wavelength at 286 nm and calibration curve was plotted over the concentrations ranging from 2-20 μg/ml of Cyproheptadine HCl with correlation coefficient 0.9973, validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.2179 and 0.6605 respectively by simple UV Spectroscopy. The proposed method was validated.

Keywords: Cyproheptadine HCl, Co-solvent, spectrophotometry and validation.


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