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Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL BENZIMIDAZOLE DERIVATIVES

A. Bouayyadi*, A. Moussaif, A. EL Hessni, A. Ouichou, B. Lakhrissi, N. EL Abbadi, M. Mzibri, A. Moutaouakkil, A. Iddar, Y. Ramlii, M. EL Faydy, A. Aiboud, A. Mesfioui and E.M. Essassi

ABSTRACT

Benzimidazole and its derivatives are known for their many
therapeutic applications and represent one of the most biologically
active classes and especially psychotropic activity. They can be used in
the conditions of inflammation, microbial infections and also in
psychotropic diseases (depression and anxiety). In this way, a new
method using Phase-Transfer Catalysis (PTC) by combining families
of Benzemidazole and Oxazoline was developed to synthesis two new
derivatives. The melting point and Thin Layer Chromatography (TLC)
was used verified the purity of the two newly synthesized compounds,
then to determine the structure, the analytical techniques of Infrared
(IR) spectral studies and Spectroscopy Nuclear Magnetic Resonance
(1H NMR) were used. The synthesized compounds will be exposed
later to toxicity studies (acute and chronic) and then to psychotropic activity tests in the way
to show its psychotropic activities.

Keywords: 2-Mercapto-Benzemidazole, 2-Amino-Benzemidazole, Benzimidazole, Oxazoline, Oxazolidinone, Psychotropic, Phase-Transfer Catalysis, Diethyl-amine.


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