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Abstract

SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A METHOD FOR ENHANCEMENT OF BIOAVAILABILITY

Poonam Kailas Ghule*, Sadik F. Sayyad and Dr. Sanjay R. Chaudhari

ABSTRACT

Most of the modern drugs are poorly aqueous soluble, having high molecular weight, pre systemic first pass effect, enzymatic degradation and limited dissolution rate shows low bioavailability. The newer and novel technologies developed in recent year to overcome such problems. One of the most new way for such a mentioned problem is the Self microemulsifying drug delivery system (SMEDDS). The SMEDDS are the isotropic mixture of oil, surfactant and co-surfactant. SMEDDS solve the problem of all BCS class of drug such as solubility, high molecular weight, pre systemic first pass effect, enzymatic degradation, gastric irritation and also increase the bioavailability and stability of drug. SMEDDS are complex mixtures in which drug quantification can become a challenging task. The hypothesis behind dissolution rate enhancement with SMEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption.. This article gives a complete overview of SMEDDS as a promising approach to effectively tackle the problem of poorly soluble molecules.

Keywords: Self micro emulsifying drug delivery system, oral bioavailability, lipid based formulations, poorly water soluble drugs.


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