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Abstract

EVALUATION OF PERIPHERAL NEUROPATHIC EFFECT OF ALOE VERA LEAVES EXTRACT IN DIABETIC RAT

Anil Shrestha*, N. C. Nagalakshmi and Shiva Kumar Swamy

ABSTRACT

Aims: To evaluate the diabetic peripheral neuropathic effect of hydroalcoholic leaves extract of Aloe vera in Streptozotocin (STZ) induced diabetic rat models. Study design: Diabetic peripheral neuropathic effect was carried out by dividing animal randomly into five groups, each containing 6 animals. Place and Duration of Study: Department of Pharmacology, Mallige College of Pharmacy, Bangalore-90, between August 2014 and April 2015. Methodology: Diabetes was induced by a single i.p. injection of 50 mg/kg streptozotocin. Grip strength, Eddy’s hotplate, Formalin test, Tail immersion test (Hot & cold water) and Pin prick test were performed to determine the extent of neuropathic pain in diabetic rats. Imipramine (10.5mg/kg), Duloxetine (20mg/kg), Aloe vera (300mg/kg) and Aloe vera (450mg/kg) was administered orally for 21 consecutive days starting after 4th week in STZ induced diabetic rats., Total cholesterol ,Triglycerides, HDL, LDL, Thiobarbituric acid reactive substance (TBARS), superoxide dismutase (SOD) and Catalase in serum were also performed to access the oxidative stress. Results: Chronic treatment with Aloe vera for three weeks starting after fourth week in STZ induced diabetic rat’s attenuated hyperalgesia. Treatment with Aloe vera at doses of 300 and 450 mg/kg p.o. daily significantly restored the reduced body weight, elevated blood sugar, reduced grip strength and lipid profiles. It also ameliorated diabetic induced raised level of TBARS and decreased level of SOD and Catalase. Conclusion: It was concluded that antidepressant, antidiabetic and antioxidant effect of Aloe vera may be responsible for observed antinociceptive and protective role against damage to the neurons in STZ induced diabetic peripheral neuropathic rat models with P<0.001.

Keywords: Aloe vera; Diabetic peripheral neuropathy; Streptozotocin; Imipramine; Duloxetine.


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