“FORMULATION,, EVALUATION AND OPTIMIZATION OF VALSARTAN LOADED MICROSPONGES FOR CAPSULE”
Kalyan P. Take*, Kailas N. Tarkase and Narayan S. Take
ABSTRACT
The aim of this study was to develop Valsartan loaded microsponges
for oral drug delivery. The quasi-emulsion solvent diffusion method
was used for microsponges formulations employing Ethyl Cellulose as
a polymer. The compatibility of the drug with formulation components
was established by FT-IR spectroscopy & DSC. Microsponge
formulations were prepared by gradually increasing the drug: polymer
ratio. The 32 factorial design was used for optimization of formulation.
The 1:1 ratio of drug:polymer was optimized. The surface morphology,
production yield, particle size and drug entrapment efficiency of
microsponges were evaluated. Shape and surface morphology of the
microsponges were examined using SEM. Particle size of prepared microsponges was
observed in the range of 126.41 ± 0.7 to 271.59 ± 0.9 μm. The drug entrapment efficiency of
the microsponges was found in the range of 74.16 to 99.73 %. The in-vitro dissolution studies
of microsponges capsule in the phosphate buffer pH 6.8 showed that drug release in stomach
could be controlled by Ethyl cellulose. Cumulative release of the microsponges formulation
batches F7 & F8 in period of 12 h upto 98.73% & 99.07%.
Keywords: Valsartan, Microsponges, quasi-emulsion solvent diffusion method, Ethyl Cellulose (EC), Polyethylene glycol(PEG), in-vitro study. Scanning Electron Microscopy (SEM). Fourier Transform Infra-Red (FTIR). Differential Scanning Calorimetry (DSC).
[Full Text Article]