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Kalyan P. Take*, Kailas N. Tarkase and Narayan S. Take


The aim of this study was to develop Valsartan loaded microsponges for oral drug delivery. The quasi-emulsion solvent diffusion method was used for microsponges formulations employing Ethyl Cellulose as a polymer. The compatibility of the drug with formulation components was established by FT-IR spectroscopy & DSC. Microsponge formulations were prepared by gradually increasing the drug: polymer ratio. The 32 factorial design was used for optimization of formulation. The 1:1 ratio of drug:polymer was optimized. The surface morphology, production yield, particle size and drug entrapment efficiency of microsponges were evaluated. Shape and surface morphology of the microsponges were examined using SEM. Particle size of prepared microsponges was observed in the range of 126.41 ± 0.7 to 271.59 ± 0.9 μm. The drug entrapment efficiency of the microsponges was found in the range of 74.16 to 99.73 %. The in-vitro dissolution studies of microsponges capsule in the phosphate buffer pH 6.8 showed that drug release in stomach could be controlled by Ethyl cellulose. Cumulative release of the microsponges formulation batches F7 & F8 in period of 12 h upto 98.73% & 99.07%.

Keywords: Valsartan, Microsponges, quasi-emulsion solvent diffusion method, Ethyl Cellulose (EC), Polyethylene glycol(PEG), in-vitro study. Scanning Electron Microscopy (SEM). Fourier Transform Infra-Red (FTIR). Differential Scanning Calorimetry (DSC).

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