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Abstract

EVALUATION OF ANTI-DIARRHEAL, CENTRAL NERVOUS SYSTEM (CNS), HYPOGLYCEMIC AND THROMBOLYTIC ACTIVITIES OF METHANOLIC EXTRACT OF TERMINALIA CITRINA LEAVES

Narhari Das*, Md. Sharif Hasan, Zobaer Al Mahmud and Sheikh Zahir Raihan

ABSTRACT

The present study was designed to investigate anti-diarrheal, central nervous system (CNS) depressant, hypoglycemic and thrombolytic effects of methanolic extracts of Terminalia citrina leaves. The antidiarrheal activity was evaluated by castor oil induced method while central nervous system depressant activity and hypoglycemic activity were evaluated by phenobarbitone induced sleeping time method and by blood glucose level test and thrombolytic activity was evaluated using in vitro clot lysis model. The extract of T. citrina significantly (p<0.01) and dose-dependently reduced the percentage of diarrhea with 25.48% at the dose of 400 mg/kg body weight and didn’t significantly prolong the phenobarbitone induced sleeping time. In a hypoglycemic evaluation of extract showed significantly (p<0.01) at 400 mg/kg body weight and showed significantly (p<0.01) having 10.74±1.27% clot lysis. The study has shown the extract of T. citrina exhibited high hypoglycemic properties, low anti-diarrheal and thrombolytic effect and no central nervous system depressant effect.

Keywords: Terminalia citrina, Anti-diarrheal, Central nervous system (CNS) depressant, Hypoglycemic, Thrombolytic.


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