WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING ALGINATE BEADS OF LAFUTIDINE BY IONOTROPIC GELATION METHOD

Dipika H. Patil* (B. Pharm) and Prashant S. Malpure (M.Pharm, Ph. D)

ABSTRACT

The present investigation aim to formulate gastroretentive floating drug delivery system of lafutidine to prolong gasric residence time, target stomach mucosa and increase the bioavailability. Lafutidine a newly developed histamine H2-receptor antagonist, it is used in the treatment of gastric ulcers, duodenal ulcers and gastric mucosal lesions associated with acute gastritis and acute exacerbation of chronic gastritis. The calcium alginate beads prepared by ionotropic gelation method using sodium alginate, hydroxyl propyl methyl cellulose and sodium bicarbonate. The developed beads were evaluated for physical appearance, micromeritic studies, particle size analysis, drug entrapment efficiency, swelling index, buoyancy studies, percentage yield, Fourier transform infrared spectroscopy (FTIR) studies, DSC Study, In vitro drug release study. The optimized formulation (F3) at the end of 12 hr shows % CDR 89.66%. The drug release data fitted in kinetic data. The optimized formulation follows zero order release kinetic and accelerated stability studies were performed for optimized batch.

Keywords: Alginate beads, Lafutidine, Gastroretentive floating drug delivery system.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More