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Abstract

FORMULATION AND EVALUATION OF SOLID NANO EMULSION OF FUROSEMIDE

Sujatha S.*, Siva Jyothi J., Krishnaveni M., Rami Reddy G. and Kishore Kumar K.

ABSTRACT

The aim of the present work is to prepare solid nanoemulsion of a
poorly water soluble drug Furosemide with aerosil as carrier. Based on
solubility studies and pseudo ternary phase diagrams, five liquid
SNEDDS were prepared with selected systems in various proportions
and evaluated for self emulsification time, phase separation and
precipitation of the drug, robustness to dilution, percentage
transmittance, thermodynamic stability studies, droplet size, PDI and
zeta potential. From the evaluation studies it was found that
formulation consisting of oleic acid(15.4%w/w), tween80(57.1%w/w),
PEG400 (17.5%w/w) and drug(10%w/w) was stable and optimum and
selected for preparation of S-SNEDDS. With selected optimum
formulation solid nanoemulsion is prepared using aerosil as carrier in 1:2 ratio by adsorption
technique and evaluated for flow properties, drug content, effect of dilution, droplet size
determination, FT–IR studies, in–vitro drug release study and accelerated stability study for
6 months. Prepared solid nanoemulsion showed “good” flow properties and 95.162±1.24%
drug content. Reconstitution properties showed spontaneous nano emulsification with droplet
size 65.02 nm and PDI 0.648. Results of in-vitro dissolution revealed that % drug release
from solid nanoemulsion was higher than that of pure drug and marketed tablet. Results of
accelerated stability study for 6 months showed that formulation was stable and no alteration
in the dissolution rate was observed. The results of present study have proved the potential use of solid nanoemulsion to improve solubility and dissolution rate of poorly water soluble drug furosemide.

Keywords: Solid nanoemulsion, Aerosil, Dissolution rate, accelerated stability Study and Furosemide.


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