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Abstract

SYNTHESIS AND CHARACTERISATION OF SOME TRIAZOLO QUINAZOLINE DERIVATIVES

Savita Dhongade-Desai*, Vitthal Divate and Poonam Shetake

ABSTRACT

A series of new 3-(substituted phenyl)-8-(substituted)-9-(substituted)- [1,2,4]triazolo[4,3-c] quinazoline derivatives were synthesized by multi- component reactions of equimolar amount of 7-(substituted)-6- (substituted)-3H-quinazolin-4-one derivatives (0.1 mmole), hydrazine hydrate (0.1 mmole) and substituted aromatic aldehyde (0.1) were mixed in 25 ml ethanol. without catalyst under microwave irradiation. The compounds were synthesized in good yields (69-91%) by the microwave- assisted one-pot protocol in much shorter reaction times. All compounds were characterized by 1H-, 13C-NMR, IR spectral analysis. Some of the compounds were found to be effective against bacterial strains. It is an efficient, promising and green synthetic strategy to construct 3-(substituted phenyl)-8-(substituted)-9-(substituted)-[1,2,4] triazolo[ 4,3-c]quinazoline skeleton.

Keywords: Quinazoline, Microwave-Assisted Synthesis, Multi-component reactions.


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