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Mohit R. Gaikwad*, S. Z. Chemate, Mubashshera S. Shaikh


Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After release of drug, the residual system is emptied from the stomach. This results in an increased GRT and a better control of the fluctuations in plasma drug concentration. Telmisartan antagonizes the effect of angiotensin II (vasoconstriction and aldosterone secretion) by blocking the angiotensin II (AT 1 receptor) in vascular smooth muscle and the adrenal gland, producing decreased BP. In the present investigation telmisartan floating tablets were prepared by using different grades of polymers such as Xanthum gum, Guar gum and Eudragit RSPO. Formulated tablets showed satisfactory results for various Post compression evaluation parameters like: tablet thickness, hardness, weight variation, floating lag time,total floating time, content uniformity and in vitro drug release. Formulation F8 containing Eudragit RSPO gave better in-vitro drug release and floating properties in comparison to the other formulations. The release pattern of the F8 formulation was best fitted to Korsmeyer- Peppasmodel and the release pattern from the formulation was non-Fickian diffusion or anomalous diffusion.

Keywords: Telmisartan, floating drug delivery, non-Fickian diffusion.

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