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Abstract

DESIGN AND BIOLOGICAL EVALUATION OF ACRYLATE NANOPARTICLES FOR IMPROVED OCULAR BIOAVAILABILITY: AN APPLICATION TO ANTI GLAUCOMA DRUG

*Parmanand Verma, Roop Narayan Gupta, Arvind Kumar Jha

ABSTRACT

Purpose of present study is to develop a novel drug delivery system for improved ocular bioavailability of antiglaucoma drug. Eudragit® RS 100 nanoparticles were prepared by Nanoprecipitation Method. Particles size and zeta potential was measured by Malvern Zetasizer, TEM was used as an aid for visualization of Nanoparticles, drug interaction study was done by FTIR spectroscopy, entrapment efficiency was determined by centrifugation technique, in vitro drug release study was done by using franz diffusion cell, Standardized Riester Tonometer was used to check Intra Ocular Pressure lowering potential of formulations. Short term stability study was done. Particle size measured was between 89.21±3.98 to 134.21±3.43 nm, all the formulations were having positive charge on surface and were almost spherical in shape, no any drug to polymer interaction was seen. Entrapment efficiency was between 52.1±2.4 to 66.1±3.1 %. Drug release was recorded for 8 hrs, means sustained delivery was achieved. The IOP lowering potential of plain drug solution in rabbit’s eye was significantly lower than Eudragit nanoparticles (***P<0.001), Formulations were stable for 3 months as seen in stability studies. Eudragit® RS 100 nanoparticles increased the ocular bioavailability of Acetazolamide and sustained the drug release for extended period of time.

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