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Abstract

FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL PATCH OF BROMOCRIPTINE MESYLATE

Niket V. Talaulikar*, Rajashree Gude, Akshata R. Shirodker and Shraddha D. Bhangle

ABSTRACT

The aim of the present study was to design and formulate matrix diffusion controlled transdermal patch of Bromocriptine Mesylate using different ratios of hydrophilic and hydrophobic polymeric combinations by solvent evaporation technique. The effects of the different ratios of polymeric combinations were studied. All the formulations were examined for several evaluation parameters like physicochemical properties, compatibility, in vitro release, and stability studies. IR results showed that there was no incompatibility between the drug and the excipients used. The prepared formulations which were evaluated for different physicochemical properties like thickness, folding endurance, drug content, surface pH, percentage moisture absorbance, percentage moisture loss, tensile strength, percentage elongation, flatness, water vapour permeation rate and skin irritancy testing exhibited satisfactory results. The drug release followed first order and Higuchi’s kinetics, which was evident from regression value. Formulation F5 was considered as optimized formulation which showed highest drug release (59.20% after 120 hours). All formulations were found to be stable after 3 months stability studies under accelerated conditions (400C and 75%RH). It was concluded that (1.5:1) ratio of Hydroxypropyl methyl cellulose K15/Ethylene cellulose produced best optimized results and can be used to enhance the transdermal permeation of the drug.

Keywords: Transdermal drug delivery, Bromocriptine Mesylate, Hydrophilic and Hydrophobic Polymers.


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