WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



*Pankaj T. Deore (B. Pharm), Parag D. Kothawade (M. Pharm), Dr. Hemant H. Gangurde (M. Pharm, Ph. D)


Metformin and Glimepiride are used to treat high blood sugar level that is caused by type 2 diabetes. In type 2 diabetes, the body does not work properly to store the excess sugar and the sugar remains in the blood stream. With two different mode of action, the combination of Glimepiride and Metformin HCl help the body cope with high blood sugar more efficiently. Immediate action of Glimepiride will be helpful to control excess sugar, which will be helpful to control excess sugar, which will be maintained by Metformin HCl action later on. Metformin HCl is considered to be absorbed in upper part of GIT it has 6 hours half-life and 50 to 60 % bioavailability. Therefore, an attempt is made to retain the dosage form in the stomach for longer period of time. This is achieved by developing Gastro Retentive Drug Delivery System i.e. Floating Drug Delivery System. These floating tablets of Metformin HCl mainly prepared for increasing the gastric residence time and release the drug up to 12 hrs thereby increasing the bioavailability of the drug leading to reduced frequency of dosing. The study discusses the preparation and evaluation of Gastroretentive bilayer tablets of Metformin HCL and Glimepiride. Immediate release layer was formulated using sodium starch glycollate (superdisintegrant), lactose (filler), talc and magnesium Stearate (lubricant). The effervescent based floating layers were formulated using sodium bicarbonate along with polymer like HPMC and Xanthan gum in 3:2 ratios was selected for formulation. Formulations F1-F3 were prepared using polymer HPMC K4M, HPMC K15M, HPMC K4100M along with other excipients such as Xanthan gum (gelling agent), sodium bicarbonate (gas generating agent),citric acid (acid component), lactose (filler) and Magnesium Stearate (lubricant). The in-vitro drug release data obtained were subjected to different kinetic models and values of different exponent (n) and regression (R2) were applied to know the mechanism of drug release from the formulations. Effect of variables like the gelling polymer concentration in combination that influenced buoyancy time, total floating time and drug release from various formulations were studied.

Keywords: Metformin HCl, Glimepiride, Gastro retentive systems, Bi-layer tablet.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More