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Abstract

STUDY OF ACUTE AND SUB-ACUTE ORAL TOXICITY ASSESSMENT OF THE POLYHERBAL EXTRACT

Shilpi Kashyap, Sunita Bhardwaj*, Dr. G.L. Gupta and Lalit Sharma

ABSTRACT

Background: Polyherbal extract of different medicinal plants are widely used for several disorders. Toxicity studies on polyherbal extract are not available. Acute and subacuteoral toxicities of Polyherbal extract in Wistar rats were evaluated in the present study. Objectives: The present investigation explored the protective effect of polyherbal extract of different medicinal plants in rats and no adverse effect ariesd. Method: In the acute toxicity study, Polyherbal extract was administered to two rats at 2000mg/kg, once orally and were observed for 14 days. No toxic signs/mortality were observed. In the sub-acute study, WSR extract was administered once daily for 28 days to rats at 500, 1000 and 2000 mg/kg, orally. No toxic signs/mortality were observed. Result and Discussion: There were no significant changes (P<0.05) in the body weights, organ weights and haematobiochemical parameters in any of the dose levels. No treatment related gross/histopathological lesions were observed. The present investigation demonstrated that the no observed adverse effect level was 2000 mg/kg body weight per day of hydroalcoholic extract of Polyherbal in rats and hence may be considered as non-toxic.

Keywords: Polyherbal extract; toxicity; safety; rats.


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