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Abstract

COMPARATIVE STUDY OF ANTIDIARRHEAL EFFECT OF THREE BANGLADESHI PLANT EXTRACTS

Md. Abdullah Al Masum, Mohammad Nazmul Islam, Mohammad Shahin Alam,
Md. Mohaiminul Islam, Md. Rabiul Hossain, Md. Nazmul Hasan, Md. Hosne Mobarak Chowdhury, Mahmudul Hasan, Mohammad Shah Hafez Kabir, Kazi Ashfak Ahmed Chowdhury*

ABSTRACT

Objective: The aim of the study to evaluate the medicinal properties of Bombax ceiba, S. colocasiifolia and P. sikkimensis as antidiarrheal. Methods: Leaves of Bombax ceiba and S. colocasiifolia was extracted with pure ethanol (EEBC and EESC) and P. sikkimensis was extracted with pure methanol (MEPS). Antidiarrheal effect was carried out by using a standard method of bioassay: Castor oil-induced diarrhea test. Result: In the castor oil-induced diarrhea conduct experiment, the leaves extract of Bombax ceiba success to produce a noticeable antidiarrheal result in the mice. At doses of 250 and 500 mg/kg, the extract produced significant inhibition of faces. The total number of wet feces produced upon administration of castor oil decreased (4.10±0.38, at 250 mg/kg and 2.90±0.45, at 500 mg/kg) compared to the control group (5.8 ± 0.2) while Loperamide decreased to 2.2 ±0.374 at the dose of 5 mg/kg. But two other plant extract (S. colocasiifolia and P. sikkimensis) failed to exhibit the antidiarrheal activity, because they increased the amount of faces in mice. Conclusion: So, we can conclude that Bombax ceiba may be good choice for searching antidiarrheal agent. Though, no other methods used to evaluate the antidiarrheal effect of B. ceiba, further studies need to evaluate the present finding and if the further studies also support that and also to establish the mechanism of action.

Keywords: Bombax ceiba, ethanol extract, antidiarrheal, castor oil.


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