WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SAPONIN EXTRACT OF ACHYRANTHES ASPERA PREVENTS OBESITY AND OXIDATIVE STRESS IN HIGH FAT DIET FED MALE WISTAR RATS

Bobbu Pushpalatha, Indireddy Ramamanohar Reddy, Netala Vasudeva Reddy, Nagam Venkateswarlu, Tartte Vijaya*

ABSTRACT

The aim of the present study was to investigate the effects of saponin rich ethanol (ASE) extract of Achyranthes aspera on obesity and oxidative stress (OS) in high fat (HF) diet fed male wistar rats. ASE administration at a dose of 120mg/kg for eight weeks along with HF significantly decreased (p<0.05) the increase in food intake(FI), body weight gain (BWG), visceral organ weights (VOWs), serum total cholesterol (TC), triglycerides (TG), very low density lipoproteins (VLDL-C), low density lipoproteins (LDL-C), atherogenic index (AI), hepatic TC and TG levels and elevated (p<0.05) the levels of serum high density lipoproteins (HDL-C), fecal TC and TG when compared to HF diet alone fed group. Elevated excretion of lipids in feces reveal impaired digestion and reduced intestinal lipid absorption by ASE which results in decreased BWG and VOWs. In HF diet alone fed group there was a significant increase in lipid peroxidation (LPx) and decrease in SOD, CAT and GPx activities accompanied by a huge accumulation of lipid droplets and macrophage infiltrations within the hepatocytes and adipocytes that could enhance the release of pro-inflammatory cytokines which in turn generate ROS and cause OS. But these alterations were not observed in ASE treated group as there was no excessive fat accumulation. These results suggest that saponins might prevent obesity and oxidative stress in HF fed rats.

Keywords:


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More