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Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL FLUOROQUINOLONE CLUBBED THIADIAZOLE ANALOGS

*Prabodh Chander Sharma, Monika Chaudhary, Mona Piplani, Archana Sharma, Harish Rajak

ABSTRACT

An efficient and facile procedure for synthesis of novel series of fluoroquinolone analogs clubbed with thiadiazoles is described herein. Antibacterial screening of synthesized compounds was carried out against a range of Gram-positive and Gram-negative bacterial strains. Some of synthesized compounds 5i (MIC: 0.625 μg/mL) and 5k (MIC: 0.3125 μg/mL) exhibited promising activities against the E. coli and S. aureus respectively. The analogs 5c, 5d, 5f and 5j displayed good anthelmintic activity against Eisemia foetida when compared with standard drug.

Keywords: Fluoroquinolones; thiadiazole; infection; antibacterial; anthelmintic.


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