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Abstract

FORMULATION AND EVALUATION OF MONOLITHIC OSMOTIC TABLET OF VALSARTAN

Aher Smita S.*, Gawai Mamata N., Saudagar Ravindra B.

ABSTRACT

Valsartan is an orally active and specific angiotensin II antagonist acting on the AT1 receptor subtype and belongs to the class of antihypertensive agents. Monolithic Osmotic Tablet of Valsartan were developed using Sodium chloride as a key ingredient which gives osmogent property which provides driving force inside the core tablet and which leads to release of drug. Microcrystalline cellulose used as a release retardant material in the present work. Different formulations were prepared by varying the concentrations using 32 factorial design. It was applied to see the effect of variables Sodium chloride and MCCon the response percentage drug release as a dependent variable. These formulations were evaluated for, Hardness, Flow property, Thickness, Friability, Drug content and In-vitro drug release. Tablets were coated with a semipermeable membrane using 5% w/v cellulose acetate in acetone and PEG 400(15%) used as Plasticizer. Coated Monolithic osmotic tablets were drilled for delivery orifice using standard micro drill of diameter size 0.6 mm on both side of tablet. Drug release rate was increased as the increase in the concentration of sodium chloride and release rate decreased on increasing the concentration of MCC. SEM Study carried out for detection of diameter size of delivery orifices. The FTIR studies demonstrate that there was no interaction between polymer and drug. The optimized formulation was stable for 6 months of accelerated stability study.

Keywords: Valsartan, MCC, NaCl, Monolithic Osmotic Tablet.


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