WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

IMMUNOLOGICAL RESPONSE AMONG HIV/AIDS PATIENTS BEFORE AND AFTER HAART THERAPY AT NORTH CENTRAL HOSPITAL, NIGERIA

*Ya’aba Y., Mohammed S.B., Uba A., Ibrahim K. and Oladosu O.P.

ABSTRACT

Human Immunodeficiency Virus (HIV), the agent that causes acquired immune deficiency syndrome (AIDS). Although, highly active antiretroviral therapy (HAART) is known to profoundly suppress viral replication, it increases CD4+ cell count and delays disease progression and death. The aim of this prospective cohort study was to describe immunological response among HIV-infected individuals receiving HAART with long-term follow-up. A Cohort prospective study design was conducted to assess immunological (CD4+ recovery) among HIV-infected individuals receiving HAART from June, 2013 to February, 2015 at ART clinics in North Central, Nigeria. Immunological determination was carried out using Flow Cytometry (Partec- cyflow, Germany), according to manufacturer’s instructions. A total of 2,322 HIV positive patients are involved in this research. The mean baseline CD4+ count was 231.7; the mean CD4 count at the 3rd, 6th, 9th, 12th and 15th month was 281.9, 327.4, 377.8, 416.5 and 466.8cells/μl respectively. There was a good immune recovery at the 3rd month of therapy from the baseline mean CD4+ T cell count of 50.2cells/μl to 235.1 cells/μl, which was statistically significant (p<0.05). This first remarkable rise was continued in the achieving in the mean CD4+ count of 327.4cells/μl at the 6th month of visit. In this study, although good CD4+ cells recovery in response to ART was documented in more than 89% of follow-up cases, HIV-positive patients were enrolled in ART program at decreased CD4+ cells levels. Therefore interventions need to be designed to promote early HIV testing and early enrollment of HIV infected individuals into ART services.

Keywords: ART, CD4+ count, HIV/AIDS, HAART, Cohort.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More