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Abstract

ANALYSIS OF INTERACTIONS OF NEOTAME AND NITROGENOUS BASES OF DNA AND RNA USING QUANTUM METHODS

Leonardo Tejero-Jimenez, Lazaro Balan-Rodriguez, María Deyanira Loya-Vargas, Manuel González-Pérez*

ABSTRACT

Neotame is a 3, 3-dimethyl substituted N-butyl group containing aspartame structural derivative. Neotame has a capacity of 7,000 to 13,000 times sweeter than sugar. The intake of sugary drinks (SD) is a concern in Mexico since 2012. Mexico ranked the first world ranking in consumption of sugary beverages. The simulation was Elaborated using HyperChem molecular simulation. The specific parameters selected for each of the simulations were done by Semi- Empirical Method (SE-PM3). The cross bands of neotame and nitrogenous bases of DNA and RNA. G: Neo shows an ETC of 24.648, it is the lowest, followed by A: Neo with 25.718 and C: Neo with 26.738 indicating increased stability, unlike other interactions. A bit ETC shows a high probability that the compounds bind. The interaction Neo: A, shows an ETC of 33.946 is unlikely to join. Because of the results indicate that the quantum simulation of Neotame vs. Nitrogenous bases of DNA and RNA is possible that neotame will be a precursor to cancer.

Keywords: Neotame, Nitrogenous bases, Quantum interaction, Quantum methods.


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