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Abstract

ANALYSIS OF NITROGEN BASES ALTERATIONS IN DNA AND RNA CAUSED BY AIR POLLUTANTS BY QUANTUM METHODS

María Deyanira Loya-Vargas, Lázaro Balan-Rodríguez, Leonardo Tejero-Jiménez, Manuel González-Pérez*

ABSTRACT

Currently, air pollution is a worldwide problem, where the main air pollutants are sulfur dioxide (SO2), nitrogen oxides (NxOx), carbon oxides (COx), particulate matter (PM), ozone (O3) and Pb due its high concentration and impact they cause. The relation of the bases is the key, and the structure of DNA has important implications, allowing processes such as DNA replication and RNA translation into protein. The formation of protein-nucleic acid associations proceeds through hydrogen bonds. The simulations realized with molecular simulator Hyper Chem (HC). We performed electronic interactions between molecules of the same, the interactions of cross-bands of the nitrogenous bases and the interactions of cross-bands of air pollutants. From these simulations we infer as the principal contribution of this study, that C can be confused with the N2O3, G can be confused with SO2; CO2; CO; O3 and with the Pb in the genesis of RNA. Because the similar value of ETC of C:G. With these findings, another avenue to explain the oncogenic and mutagenic effects of N2O3, SO2, CO2, CO, O3 and the Pb on the human body are proposed in conjunction with the novel ETC method.

Keywords: Air pollutants, Nitrogenous bases, Cancer, Quantum Methods.


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