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Abstract

STUDIES IN TYPE 2 DIABETIC PATIENTS ON CD36GENE AND THE LEVELS OF LIPPROTEIN IN IRAQ

Wesen Ibrhium, Mohammed Ibraheem Nader and Ilham A. Khalaf

ABSTRACT

The aim of study to findig the relationship between the polymorphism of cd36 gene and the risk of developing diabetes type II (T2DM) in Iraqi patients. The single nucleotide polymorphism (SNP) in a gene cd36, and their receptors in patients with diabetes and hardening of the arteries, heart disease and blood vessels is a considerable importance as it is the gene responsible for the absorption of free fatty acids and antioxidant specificity a low-density, (LDLox). The study included eighty patients with T2DM patients with diabetes Type II and reviewers to diabetes of the center and /school of Medicin research at Mustansiriya University between April 2015 and April 2016, fortysample of healthy ostensibly individuals 20 males and 20 females ranged in age study samples between (35-73 years). Information of Samples was collected in the form of a questionnaire for patients. DNA extract from blood samples collected from patients T2DM and healthy individuals using BIONEER kits, then the molecular diagnosis of exons using four special primers (exon 3 a molecular volume is 265 bp, Exon 4 a molecular volume is 358 bp and Exon 14 with amolecular volume is 313 bp and Exon 15 with a molecular volume is 250 bp) in cd36 gene using polymerase chain reaction program (PCR) and electrophoreses through a garose gel. The statistically analyzed of clinical results for systolic blood pressure (SBP), blood fasting sugar (FBS), sugar hemoglobin (% HbA1c), triglycerides (TG), low-density lipoprotein (LDL) and lipoprotein very low density (VLDL) in T2DM cases compared with healthy controls, as found significant differences on the level (p <0.05). Sequence of gene analysis in CD36 gene in Iraqis patient and healthy people have shown they have mutations deleted in exons 3 and 4 of Frameshift type and these mutations are responsible for the disease, type 2 diabetes, and to delete the 16bp area in exon 14 and the presence of a mutation in exon 15 is G> C all of these mutations caused T2DM. The genetic study of diversity in a gene associated with diabetes, and so is this gene is important in tracking the candidate T2DM.

Keywords: Type 2 diabetes mellitus (T2DM), polymerase chain reaction (PCR), cluster of differentiation (CD36), Exons.


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