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Abstract

STUDY THE EFFECT OF QUERCETIN ON FSH AND ESTROGEN GENE EXPRESSION IN FEMALE WISTER RATS EXPOSED TO OXIDATIVE STRESS BY LEAD ACETATE

*Zahraa Hussien AL-Moosawi and Hayder A. N. Al-zamely

ABSTRACT

This study was aimed to evaluate the effects of Quercetin to improve efficiency of the female reproductive system of wester rats which exposed to oxidative stress by lead acetate. 40 mature female rats were used with weights at (180± 20 gm) and randomly divided into equal 4 groups (10 animals in each group). group 1(control group) received drinking water freely, group 2: administered Querctin (300mg/kg) orally once daily for 60 days, group 3: administered daily dose of lead acetate (10mg /kg) orally, once daily for 60 days and group 4: administered daily dose of lead acetate (10mg/kg) orally for 30 days and then administered Quercetin (300mg/kg) orally once daily for another 30 days. after 60 days the animals were sacrificed and samples of ovary and pituitary glands was taken for gene expression study for Aromatase cytochrome P450 gene, FSH beta subunit gene and FSH receptor gene The results were as follows: gene expression of estrogen showed a significant increase (p<0.05) in (T1) compared with control groups and T2, while results of T2 showed significant decrease (p>0.05) in compared with other groups, also there was a significant increase(p<0.05) in (T3) compared with control group and T2.while the results gene expression of FSH receptor gene showed significant increase (p<0.05) in T1 in compare with T2 and control group, also significant increase (p<0.05) in T3 compared with control groups and T2, while T2 showed significant decrease (p> 0.05) compared with other groups. In the same time the results of gene expression of FSH beta subunit gene showed significant increase (p < 0.05) in T1 compared with control groups and T2, also showed significant decrease (p> 0.05) inT3 compared with T1 andT3, and T3 showed significant increase (p<0.05) compared with T2 and control group.

Keywords: Quercetin, lead acetate, gene expression, antioxidants, Oxidative stress.


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