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Abstract

ANTICATARACT EFFECT OF THE ETHANOL EXTRACTS OF PERSEA AMERICANA AND ACTINIDIA DELICIOSA ON SODIUM SELENITE INDUCED CATARACT IN WISTAR ALBINO RATS

*Indumathi Parameswaran and Vijayalakshmi Krishnamurthi

ABSTRACT

The effect of ethanolic extracts of Persea americana and Actinidia deliciosa on the oxidative stress parameters of sodium selenite induced cataract in Wistar albino rats was studied. The experimental rats were grouped into 6: Group I – Normal controls, Group II – sodium selenite cataract induced animals (developed cataract), Group III – Persea americana extract co-treated animals, Group IV –Actinidia deliciosa extract co-treated animals, Group V – Persea americana and Actinidia deliciosa extract co-treated animals (animals were co- treated for 28 days with each of the plant extract after sodium selenite induction) Group VI – standard Ascorbic acid co-treated animals(animals were co- treated for 28 days after sodium selenite induction). Body weight, organ weight and insulin level of selenite induced cataract animals decreased while plant treatment prevented this loss. Increase in values of glucose, glycated haemoglobin, creatinine, urea and uric acid levels were observed in selenite induced cataract rats, while plant treated groups restored these levels. The changes in lipid profile in Group II rats were prevented by treatment. Animals with sodium selenite induced cataract showed elevated levels of lipid peroxides and conjugated dienes, while Persea americana, Actinidia deliciosa and Ascorbic acid co-treated groups showed lower levels. Enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione S transferase) activities decreased in rats with sodium selenite cataract while both the plant and standard ascorbic acid co-treated animals showed increased enzymatic antioxidant levels. Similarly, levels of non-enzymatic antioxidants such as vitamin C and total protein decreased in sodium selenite cataract rats, while both the plant and standard ascorbic acid treated animals showed increased levels. The above results thus, signify the antioxidative and anticataract potential of both Persea americana and Actinidia deliciosa.

Keywords: Selenite induced cataract, Persea americana, Actinidia deliciosa, Oxidative stress, Antioxidants.


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