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Abstract

A STUDY OF PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF EUPHORBIA HIRTA LINN WHOLE PLANT IN RATS & MICE

Madhusha Reddy Y and Praveen Kumar Uppala*

ABSTRACT

Objective: To investigate hepatoprotective of extract of Euphorbia hirtawhole plant in rats and mice. Methods: The hepatoprotective activity of the alcoholic extract of Euphorbia hirtawhole plant was tested against carbon tetrachloride and paracetamol induced hepatotoxicity in albino rats. The degree of protection was determined by measuring levels of biochemical markers like SGOT, SGPT, ALP, Bilirubin, the histopathological studies were also carried out.Silymarin was used as the standard drug for comparison. In vitro antioxidant studies were also carried out. Results: Administration of alcoholic extract of Euphorbia hirtawhole plant (200 and 400 mg/kg) markedly reduced carbon tetrachloride and paracetamol induced elevation of SGOT, SGPT, ALP, Bilirubin and cholesterol whereas HDL levels were elevated. Significant increase in GSH level and scavenging activity and decreased lipid peroxidation. The results were comparable with the standard. A comparative histopathological study of liver exhibited all most normal architecture as compared to control group. Conclusion: Alcoholic extract of Euphorbia hirta whole plant possess significant hepatoprotective activity, showed excellent resortstion of depleted levels of GSH. Alcoholic extract of Euphorbia hirtawhole plant has significant invitro lipid peroxidation and scavenging activity among other polar extracts.

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