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Abstract

AN INSIDE STORY OF ORGANO-PHOSPHOROUS POISONING: ITS LETHAL COMPLICATIONS

Dr.Md Amer Khan*, Dr.Arshad Hussain Mohd, Dr.Nasser M., Dr.Aamer K, Dr. M.S Adil1, MD Omer

ABSTRACT

According to World Health Organisation (WHO), An estimate of 2 million people attempt suicide every year worldwide. The incidence rate of organophosphorous poisoning were estimated 102,705 cases, among which india is the highest. Organophosphate is the commonest poison for accidental or suicidal deaths which are used for controlling the pest. Morbidity and mortality are due to insufficient respiratory management, delayed intubation, cardiac complications, aspiration pneumonia,weakness and neuropathy. Most organophosphates are highly lipid soluble compounds and are well absorbed from intact skin, oral mucous membranes, conjunctiva and the gastrointestinal and respiratory tracts. Organophosphorus compounds are acid-transferring inhibitors of cholinesterase. They cause cholinesterase to become firmly (and sometimes irreversibly) phosphorylated by which the action of cholinesterase will be inhibited. Accumulation of acetylcholine causes overstimulation of both muscarinic and nicotinic receptors, and subsequently disrupts the transmission of nerve impulses in both the peripheral and central nervous system. The complications of organophosphorous poisoning categorized into: Acute Cholinergic Crisis, intermediate syndrome, Delayed Polyneuropathy, cardiac menisfestation.The antidotes used for OP are Pralidoxime, Glycopyrolate, Atropine. Among which atropine is commonly used. Symptomatic treatment is necessary in the management of complications of organophosphorous poisoning.

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