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Abstract

THE H+/K+ ATPase INHIBITORY ACTIVITY OF ETHANOLIC EXTRACT OF DIOSPYROS PANICULATA Dalz BARK

Mithun K. Sebastian* and Shan P. Mohammed

ABSTRACT

The Diospyros Paniculata is a folkforic medicine which has been used in Ayurveda and Siddha system of medicines. It has been commonly used in the treatment of ulcer, burns, poisoning etc. The present study is conducted to evaluate the In vitro H+/K+ ATPase inhibitory activity of ethanolic extract of Diospyros Paniculata (EEDP). H+/K+ ATPase inhibition assay was performed by using different concentration of EEDP ranging from 10-50μg/ml and % inhibition calculated which is compared with the standard drug lansoprazole. The results obtained indicate that the EEDP has significant In vitro H+/K+ ATPase inhibitory activity (P<0.001).IC 50 value of the EEDP is 26μg/ml and the IC 50 value of Standard drug lansoprazole is 18μg/ml. The ethanolic extract of Diospyros Paniculata is having good H+/K+ ATPase inhibitory action.

Keywords: Diospyros Paniculata, In vitro, H?/K+ ATPase.


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