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Abstract

BUCCAL TABLETS OF SALBUTAMOL SULPHATE; DEVELOPMENT AND EVALUATION

Abhishek Sharma*, Shantha Kumar V, Prasanth V.V, Sam. T. Mathew, Rinku Mathappan, Ajay Chauhan

ABSTRACT

The present investigation is oriented towards improving the availability of drug for better therapeutic action through the novel concept of drug delivery. Salbutamol sulphate is a selective β2-adrenergic agonist and is an effective drug for the treatment of asthma and the symptomatic alleviation of bronchospasm. In the present work an attempt has been made to formulate and evaluate buccal tablets of salbutamol sulphate by direct compression method. Buccal tablets of salbutamol sulphate were prepared using polymers like Carbopol 934P, HPMC K4M, chitosan, sodium CMC, PVP K30. The prepared tablets were evaluated for various post compression parameters. The drug content was 97.10 0.22 to 99.21 0.08 %, weight variation was below 7.5%, thickness was 4.01 0.06 to 4.21 0.02 mm and hardness was 5.15 0.10 to 6.44 0.18 kg/cm2. The percentage friability was found to be 0.34 0.12 to 0.46 0.02 % with surface pH values in range of 6.14 0.04 to 7.15 0.02. The mean bioadhesive strength values were found to be 7.66 0.04 to 14.05 0.10 gm and all formulations showed higher swelling indices because of presence of water soluble diluents and polymers. In vitro drug release showed that more than 85% of the drug was released from formulations within 8 h. Among all the formulations, F8 was considered to be the best formulation which showed drug release of 98.47% with cumulative permeation of 88.44%. Accelerated stability study was carried out according to ICH guidelines (755% RH) for the optimized formulation and results showed there were no significant changes in weight, residence time and drug content.

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