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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF HYDROCHLOROTHIAZIDE AND IRBESARTAN IN COMBINED DOSAGE FORM BY RP HPLC

J. K. D. Tejaswi*, Dr. R. Govinda Rajan and K. Nagaraju

ABSTRACT

A simple, precise, rapid and accurate RP-HPLC method has been developed for the estimation of Irbesartan and Hydrochlorothiazide in tablet dose forms having Labindia UV 3000 as detector by Isocratic technique, using Symmetry (C18) YOUNGLIN, 150mm×4.6mm column, Potassium dihydrogen orthophosphate as buffer and Buffer: Acetonitrile: Methanol (30:10:60) as mobile phase in various proportions in combination at 231nm and 273nm. The method was found to be linear (r>0.999), precise (RSD: 0.96 for Irbesartan, 0.905 for Hydrochlorothiazide) and accuracy (mean percentage recovery fields 99.13% for Irbesartan, 98.94% for Hydrochlorothiazide). The proposed HPLC method was simple, precise because of commonly used buffer and shorter run time (8 min). The mean percentage recovery (> 95%) indicates the reproducibility and accuracy of new developed method. The results obtained in this research work clearly indicated the method can easily and conveniently be adopted for the routine estimation and determination of combined dosage form of Irbesartan and Hydrochlorothiazide.

Keywords: Irbesartan, Hydrochlorothiazide, Acetonitrile, Methanol, RP-HPLC, Mobile Phase.


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