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Abstract

FORMULATION AND EVALUATION OF AN OPHTHALMIC IN-SITU GEL OF GENTAMICIN SULPHATE

Ashish Namdeo, Santosh Bhadkariya, Akanksha Garud*, Navneet Garud

ABSTRACT

The aim of the present study is to prepare and evaluate an ophthalmic in-situ gel formulation of gentamicin sulphate. The different gelling solutions were made with Pluronic F127 in combination with different polymers such as Carbopol 934 and HPMC, which acted as a viscosity‐enhancing agent. Suitable concentrations of buffering agent were used for pH adjustment. All the formulations were sterilized in an autoclave at 121°C for 15 minutes. The formulations were evaluated for clarity, pH measurement, gelling capacity, drug content, rheological study, sterility testing, in vitro drug release study, antibacterial activity, ocular irritation study and stability study. The developed formulations exhibited sustained release of drug from formulation over a period of 8 hours. The prepared formulations were tested for eye irritation on albino rabbit (male). The formulations were found to be non-irritating. Thus, the in situ gelling systems may be used as an alternative to the conventional systems.

Keywords: Gentamicin sulphate, in situ gel, in vitro drug release, rheological study.


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