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Abstract

SHOREA ROBUSTA BUTTER AS NOVEL AND NATURAL SUPPOSITORY BASE FOR FORMULATION AND EVALUATION OF MULTILAYERED RECTAL SUPPOSITORIES

Suchitra S. Mishra*, Kanchan P. Upadhye and Gouri R. Dixit

ABSTRACT

The rectal route though rarely the first choice of drug administration serves as an alternative to oral and invasive administration. Rectal drug delivery is so pivotal when the oral medication is not possible, intra venous access is not possible and the patients have difficulty in swallowing, nausea and vomiting and for infants or children. Suppository prepared from the novel natural base is attracting considerable attention for rectal drug delivery. They are renewable, economic, easily available, nontoxic and have its own medicinal properties In the present investigation an attempt has made to formulate multilayer suppository incorporating herbal base I.e. Shorea robusta butter. Suppositories were fabricated by Shorea robusta butter as base and Levodopa and Selegilline as drug by using pour molding method. From the studies it was found that the Sal fat suppositories had good appearance, good mechanical strength and good drug release properties. Above all it remains solid at room temperature and possess the melting temperature in the range of 30 – 36 C which is an important prerequisite of any suppository base. The stability studies also revealed the satisfactory results. The studies suggested that Sal fat may be used as a base for conventional immediate release suppositories as it has been found that it possesses all the characteristics as possessed by ideal suppository base.

Keywords: Suppository, Shorea robusta butter, pour molding, prerequisite, ideal suppository base.


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