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S. Parthiban* and G. P. Senthil Kumar


Objectives: The specific objective of the study is to formulate and evaluate the proliposomal gel of Repaglinide for effective transdermal drug delivery. Method: Proliposomes of Repaglinide were prepared by thin film hydration technique by using vacuum rotary evaporator and varying the composition sorbitol, soya lecithin and cholesterol. Proliposome formulations were characterized for compatibility, vesicle size, drug content, entrapment efficiency, surface morphology, zeta potential, in-vitro drug release. The proliposomal gel was prepared for optimized proliposomal formulation RF3 and RF6 by incorporated into 1%W/V Carbopol gel. The in-vivo skin irritation study and hypoglycemic activity was carried out for the gel PLG1 and PLG2. Results: Drug and physical mixture were characterized by FTIR, the result of IR and study showed that no interaction between drug and polymers and other formulation parameters of formulated proliposomes and proliposomal gel are evaluated which showed better results. Conclusion: The drug-excipients compatibility by FT-IR confirmed no significant interaction between drug and selected excipients. Proliposomal gel PLG1 and PLG2 were proved nonirritant and more hypoglycemic effect as compared to oral formulation because it provide reduction in glucose level with controlled manner upto 24 hr. Hence, proliposomes drug delivery system was better choice for controlled release of drug through topical drug delivery.

Keywords: Repaglinide, Proliposome, Mannitol, Sorbitol, Soya lecithin, Hypoglycemic, Controlled release.

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