WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION, OPTIMIZATION AND DEVELOPMENT OF ALBENDAZOLE TABLET FOR THE IMPROVEMENT OF ORAL BIOAVAILABILITY

*Hanmant B. Salunkhe, Karmude K. T., Gurav Y. A. and Sandeep Walasangikar

ABSTRACT

Albendazole is a benzimidazole carbamate with a broad anti-parasitic spectrum. Albendazole was first approved for treatment of helminth infections in sheep in 1977, and subsequently approved for human use in 1983. In general, most ascariasis, trichuriasis, enterobiasis and hookworm infections can be successfully treated with single dose Albendazole and strongyloidiasis with multiple doses of Albendazole. The increase in bioavailability is possible by in vitro drug dissolution method. The physicochemical property of most drugs that has greatest influence on their absorption characteristics from the GIT is dissolution rate. The in vivo test is extremely costly, tedious, time consuming besides exposing the healthy subject to hazards of drug. The in vitro method is inexpensive. The best available tool today which can at least quantitatively assure about the biological availability of a drug from its formulation is its in vitro dissolution test. Enhancement of bioavailability of hydrophobic drugs is one of the major challenges in drug development of the plethora of pharmaceutical technologies available to address this issue viz. micronization, the use of surfactants.

Keywords: Micronization, Surfactant, superdisintegrants.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More