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Abstract

ONE POT SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL CHALCONES AND PYRAZOLES FROM CYCLIC IMIDES UNDER MICROWAVE IRRADIATION

Prashant P. Chaudhari and Shankarsing S. Rajput*

ABSTRACT

In this research, an efficient one-pot synthesis of novel class of chalcones and pyrazoles has been developed via reaction of cyclic imides, p-chloro benzaldehyde/hydrazine hydrate in presence of catalyst neutral alumina. Chalcones and pyrazoles as heterocyclicmoieties privileged meditative arena and are prepared via carbonheteroatom and carbon-carbon bond formation. The current methodology contribute a novel and efficient method for the synthesis of chalcones and pyrazoles with some advantages such as excellent yields, short reaction time, better recoverability and low catalyst lading. The compounds were abandoned for antimicrobial activities against bacterial strains gram positive bacteria Staphylococcus aureus, Bacillus subtilis and gram negative bacteria Escherichia coli, Pseudomonas aeruginosa along with two fungal strains Candida albicans and Aspergillus niger. Some of the compounds displayed symbolic inhibitory activity against the bacterial and fungal strains.

Keywords: Cyc l i c Imide s , Chalcones, Pyrazoles, Antimicrobial, Anti bacterial, Anti fungal.


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