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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

INTRAMUSCULAR DEXMEDITOMIDINE AND MIDAZOLAM AS A PREMEDICATION IN PAEDIATRIC SURGICAL PATIENTS, A DOUBLE BLIND RANDOMIZED CONTROL STUDY

*Dr. Kapurkar Vilas S. MD (Anaesthesiology)

ABSTRACT

Aims and Objective-  To compare between intramuscular Dexmeditomidine and Midazolam as premedication in paediatric surgical an aesthesia.  To compare anxiolysis produced by Dexmeditomidine and Midazolam perioperatively.  To study the post operative recovery by analgesic requirement in patients receiving Dexmeditomidine compared with Midazolam. Materials and Methods: A prospective randomized, double blind study involving 60 children undergoing short procedures was conducted. The patients were divided in to 2 groups each involving 30 patients. One group received Dexmeditomidine 1.5 mg/kg and other received Midazolam 0.05mg/kg IM 45 min preoperatively. The efficacy of sedation was assessed using Ramsay Sedation Score. Results: Hemodynamic parameters between the 2 groups were comparable. All sedation scores were comparable in the Dexmeditomidine and Midazolam group. Only 3 children required postoperative analgesia in Dexmeditomidine group, while 7 children in Midazolam group required postoperative analgesia. Conclusion: Dexmeditomidine facilitates adequate sedation as premedication as compared to Midazolam.

Keywords: Dexmeditomidine and Midazolam.


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