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Abstract

COMPARATIVE STUDY ON EFFECT OF NATURAL AND SYNTHETIC SUPERDISINTEGRANTS IN THE FORMULATION OF FAST DISSOLVING TABLETS OF HYDROXYZINE HYDROCHLORIDE

Neeharika.V*, Kavitha D, Husnien Ali M.M, Lakshmi P.K.

ABSTRACT

The main objective of the study was to compare the effect of natural and synthetic super disintigrants in the formulation of fast dissolving tablets of Hydroxyzine hydrochloride prescribed in the treatment of itching and as anti-anxiety agent. The mucilages were evaluated for physico-chemical parameters and they comply with the official specifications. The drug and excipients compatibility study by FTIR revealed no interaction between drug and excipients. Hydroxyzine hydrochloride tablets were prepared by direct compression method using different percentages of isabgol and hibiscus mucilages and synthetic super disintigrants like sodium starch glycolate and Kyron T- 314 and were evaluated. The optimized formulations of isabgol (HI10), hibiscus (HH10) mucilages and kyron T-314 (HK3) showed less disintegration time of 29, 32 and 31 seconds respectively. The in-vitro drug release profile of all formulations was above 90% within 20 minutes. In comparison, formulation with isabgol (9%) and hibiscus mucilage (9%) showed less disintegration time than sodium starch glycolate but formulations with isabgol (2.4%) and hibiscus mucilage (2.4%) showed more disintegration time than Kyron T-314 (2.4%) and synthetic super disintigrant Kyron T-314 is used at low concentrations as natural super disintigrants can be used at higher concentrations as these are biodegradable, cheap, and biocompatible and less toxic.

Keywords: Fast dissolving tablets, Hydroxyzine hydrochloride, Mucilage of isabgol, mucilage of hibiscus, Kyron t-314, sodium starch glycolate.


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