WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

STUDY ON DNA DAMAGE AND OXIDATIVE STRESS AND SOME BIOCHEMICAL ALTERATIONS OF LONG TERM ADMINISTRATION OF ALPHA-2 DELTA (α2-δ) LIGAND PREGABALIN AND THE POSSIBILITY OF ZINGIBER OFFICINALE IN AMELIORATING THESE EFFECTS IN RATS

*Kamel M. A.

ABSTRACT

The present study was carried out to examine the protective effect of Zingiber officinale against the possible harmful effects induced by the α2-δ ligand, pregabalin, a novel antiepileptic drug with demonstrated efficacy. The results of this study put on show that the highest DNA damage (tail length, tail DNA % and tail moment) was in the group which received pregabalin only. The serum activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT) and gamaglutamyl transferase (γ-GT) were significantly increased in pregabalin treated group whereas, a significant decrease in serum total proteins was observed. The obtained results showed a significant decrease in both superoxide dismutase (SOD) and catalase (CAT) activities in pregabalin administered group. Zingiber officinale (Ginger) administration before pregabalin for two weeks then its co-administration with pregabalin concurrently till the end of the experiment (90 days), showed lower DNA damage (tail length, tail DNA % and tail moment), with a significant improvement in serum ALP, ALT and γ-GT besides clinical improvements in serum total proteins levels. Antioxidant enzymes SOD and CAT values showed significant increase. From the obtained results, it could be concluded that pregabalin in a dose of 20mg/kg body weight does has an oxidative DNA damage, elevating some serum biochemical parameters related to liver and produce an oxidative stress. The pretreatment with ginger two weeks before the co-administration of both drugs significantly minimize those harmful effects and considered to be a valuable aid in minimizing the hazards of pregabalin.

Keywords: Pregabalin, Ginger, Comet assay, Oxidative stress, Liver enzymes.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More