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Abstract

EFFECT OF BINDER TYPE AND CONCENTRATION ON PHYSICAL AND IN VITRO PROPERTIES OF DICLOFENAC POTASSIUM 50MG TABLET

Alaa E. Elawni*, Mohammed Abdeen, Waleed Elballa, Abdelrhman Abdelkreem, Abutalib Alamin Abdallah

ABSTRACT

The aim of this study is to investigate the effect of different binder types on the pharmaceutical properties of Diclofenac potassium tablets. Nine formulation runs were prepared using 3 binders: Microcrystalline cellulose 101 (Vivapur® 101), Pregelatinized starch (Lycatab®) and Maize starch. Each used in 3 different concentrations (15%, 35% and 55%).All the formulation runs were subjected to weight variation, hardness, friability, disintegration time and dissolution tests. The results have shown that different binders with different concentrations will result in different weight variation, hardness, friability, disintegration time and dissolution profile (drug release).From this study it has been concluded that using maize starch as a binder with 35% concentration led to the best physical properties with acceptable dissolution profile regarding similarity with the originator (Cataflam®).

Keywords: Diclofenac potassium, binder type, binder concentration, dissolution profile, similarity factor.


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