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Abstract

CORRELATION BETWEEN CYTOTOXIC T-LYMPHOCYTES CD8 WITH SQUAMOUS CELL CARCINOMA OF GINGIVAL ORAL PATIENTS BY USING IMMUNOHISTOCHEMICAL ASSAY

Noor Al- Huda Ali A. H. Saeed*

ABSTRACT

Squamous cell carcinoma occurance and mortality from the gingival have increased during the recent years. while, the current study was designed to determined the correlation of tumor infiltrating cytotoxic T-lymphocyte CD8 in some Iraqi patients with gingival squamous cell carcinoma by using immunohistochemical technique. Thirty specimens were collected during the period between September 2015 until march 2016. The histological types included 19 well differentiated GSCC, 3 moderately differentiated and 8 poorly differentiated GSCC. Cytotoxic T-lymphocytes was detected immunohistochemicaly in 12 out of 30, positive results of cytotoxic T-lymphocytes was related in highly significant with each of age, gender, stage and grade of the tumor. It could be concluded from our study that immunohistochemical assay for detection of CD8 Tlymphocytes was useful in the clinical evaluation of patients with gingival squamous cell carcinoma, also it is seemed to be an additional prognostic marker that was associated with well, moderate and poor differentiated of the tumor.

Keywords: Squamous cell carcinoma, T-lymphocytes.


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