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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF METFROMIN HCL FOR FAST DISSOLVING DRUG DELIVERY SYSTEM

Warsha Pant*, Ashutosh Badola and Preeti Kothiyal

ABSTRACT

The main objective of present study was to deal with develop fast dissolving drug delivery system of Metformin HCl using Film Forming Polymer (HPMC K100 M) and Saliva stimulating agent (Citric acid) Fast dissolving forming polymeric formulation drug delivery system is in film or thin strip form in the time of administration in the body, and once administered, that undergoes fast release of drug from the film formulations. Metformin hydrochloride is a novel drug in class of biguanide used as an anti diabetic to treat the NIDDM. The bioavailability of a drug and its therapeutic effectiveness are often influenced by route of administration. So the reason for an attempt was made to formulate and evaluate fast dissolving thin oral films containing Metformin HCl as a model drug by solvent casting method using different concentrations of polymers like HPMC K100 M. Various formulations were formulated with different concentration of disintegrating agents like Crospovidone and Sodium starch glycolate. Citric acid was used as saliva stimulating agent and Propylene glycol used as a plasticizer. The prepared oral thin films were evaluated for their physicochemical and as well as mechanical parameters such as Physical appearance, surface texture (SEM), Weight uniformity of films, surface pH of films, uniformity in thickness, disintegration time of films, drug content uniformity, folding endurance, in-vitro drug release for the films formulated. It was concluded that Formulations F5, F7, F6 and F4 shows maximum release of drug. The formulation F5 was found most optimized. The Formulation F5 is having average weight 82.53±0.31 mg, thickness 0.182±0.050 mm and maximum folding endurance 291±5.The formulation F5 shows minimum disintegration time 08±2 second and maximum drug release 99.15 % in 10 minutes. Hence the formulation F5 was found to be the most optimized formulation.

Keywords: Crospovidone and Sodium starch glycolate.


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