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Abstract

A REVIEW: QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP

Prashanti Ch*, Reenu Yadav

ABSTRACT

Earlier, for a specific activity the process of drug research was confined to the empirical testing of a large number of compounds. Based on one’s synthetic abilities the lead compound thus obtained was further altered. Medicinal chemist was like a compulsive gambler who hoped that his next compound will be more active. This ‘Edisonian’ approach was too expensive and success rate was too low. The process was made more rational by many attempts. A landmark in this direction was the idea of QSAR proposed by Hansch and his coworkers. He converted the qualitative relationship like “chloro derivative is more active than bromo” to a quantitative structure activity relationship (QSAR). The paradigm of Hansch approach influenced every discipline of drug research. From that time, the medicinal chemistry is never the same again. Later, enlarging the scope of QSAR many more methods were introduced.

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